Vitamin D and disease severity in bronchiectasis

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Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis.

INTRODUCTION Vitamin-D deficiency has been linked to an increased risk of respiratory infections. The objective of this study was to determine the frequency and clinical importance of vitamin-D deficiency in patients with bronchiectasis. METHODS 25-hydroxyvitamin-D was measured by immunoassay in 402 stable patients with bronchiectasis. Patients were classified as vitamin-D deficient (serum 25...

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Author response—vitamin D deficiency and systemic inflammation in bronchiectasis.

Dr Charles Shee raises a further possible explanation for our finding of an association between vitamin D status and disease severity in bronchiectasis, that low vitamin D status represents a negative acute phase response to acute inflammation. Our study was cross-sectional and was unable to establish whether vitamin D deficiency is a cause or consequence of bronchiectasis. Possible explanation...

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 Background and purpose: COVID-19 is a viral respiratory disease that results in high mortality. Evidence suggests that micronutrients affect viral and bacterial infections. This study was performed to evaluate the effectiveness of micronutrients (vitamin D, vitamin C, and selenium) on the disease severity in patients hospitalized with COVID-19. Materials and methods: This retrospective cross-...

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Vitamin D is important in multiple aspects of health and its effects are mediated through the Vitamin D Receptor (VDR). We wanted to test the hypothesis that specific haplotypes of the VDR gene are associated with markers of disease severity, inflammation and bone health in Sickle Cell Disease (SCD). Genotyping was performed on DNA specimens from 1141 study participants in the NIH-funded Silent...

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ژورنال

عنوان ژورنال: Respiratory Medicine

سال: 2019

ISSN: 0954-6111

DOI: 10.1016/j.rmed.2019.01.009